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PDGFRα signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2–ERK1/2–p90(RSK) and AKT signaling pathways
In fibroblasts, platelet-derived growth factor receptor alpha (PDGFRα) is upregulated during growth arrest and compartmentalized to the primary cilium. PDGF-AA mediated activation of the dimerized ciliary receptor produces a phosphorylation cascade through the PI3K–AKT and MEK1/2–ERK1/2 pathways lea...
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| 發表在: | J Cell Sci |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Company of Biologists
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4481637/ https://ncbi.nlm.nih.gov/pubmed/23264740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.116426 |
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