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Human DNA Polymerase ν Catalyzes Correct and Incorrect DNA Synthesis with High Catalytic Efficiency

DNA polymerase ν (pol ν) is a low fidelity A-family polymerase with a putative role in interstrand cross-link repair and homologous recombination. We carried out pre-steady-state kinetic analysis to elucidate the kinetic mechanism of this enzyme. We found that the mechanism consists of seven steps,...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Gowda, A. S. Prakasha, Moldovan, George-Lucian, Spratt, Thomas E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481228/
https://ncbi.nlm.nih.gov/pubmed/25963146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.653287
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