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Active site interactions impact phosphoryl transfer during replication of damaged and undamaged DNA by Escherichia coli DNA Polymerase I
Replicative DNA polymerases are able to discriminate between very similar substrates with high accuracy. One mechanism by which E coli DNA polymerase I checks for Watson-Crick geometry is through a hydrogen bonding fork between Arg668 and the incoming dNTP and the minor groove of the primer terminus...
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| Pubblicato in: | Chem Res Toxicol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5696056/ https://ncbi.nlm.nih.gov/pubmed/29053918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00257 |
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