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Yeast DNA Polymerase ϵ Catalytic Core and Holoenzyme Have Comparable Catalytic Rates

The holoenzyme of yeast DNA polymerase ϵ (Pol ϵ) consists of four subunits: Pol2, Dpb2, Dpb3, and Dpb4. A protease-sensitive site results in an N-terminal proteolytic fragment of Pol2, called Pol2(core), that consists of the catalytic core of Pol ϵ and retains both polymerase and exonuclease activit...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Ganai, Rais A., Osterman, Pia, Johansson, Erik
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319046/
https://ncbi.nlm.nih.gov/pubmed/25538242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.615278
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