Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic β-Cells

Hyperinsulinemia (HI) is elevated plasma insulin at basal glucose. Impaired glucose tolerance is associated with HI, although the exact cause and effect relationship remains poorly defined. We tested the hypothesis that HI can result from an intrinsic response of the β-cell to chronic exposure to ex...

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Udgivet i:J Biol Chem
Main Authors: Erion, Karel A., Berdan, Charles A., Burritt, Nathan E., Corkey, Barbara E., Deeney, Jude T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481219/
https://ncbi.nlm.nih.gov/pubmed/25934392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.620351
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