Direct Stimulation of Islet Insulin Secretion by Glycolytic and Mitochondrial Metabolites in KCl-Depolarized Islets

We have previously demonstrated that islet depolarization with 70 mM KCl opens Cx36 hemichannels and allows diffusion of small metabolites and cofactors through the β-cell plasma membrane. We have investigated in this islet “permeabilized” model whether glycolytic and citric acid cycle intermediates...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Pizarro-Delgado, Javier, Deeney, Jude T., Corkey, Barbara E., Tamarit-Rodriguez, Jorge
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5112877/
https://ncbi.nlm.nih.gov/pubmed/27851770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166111
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