Iron toxicity in the retina requires Alu RNA and the NLRP3 inflammasome

Excess iron induces tissue damage and is implicated in age-related macular degeneration (AMD). Iron toxicity is widely attributed to hydroxyl radical formation through Fenton's reaction. We report that excess iron, but not other Fenton catalytic metals, induces activation of the NLRP3 inflammas...

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Publicado en:Cell Rep
Autores principales: Gelfand, Bradley D., Wright, Charles B., Kim, Younghee, Yasuma, Tetsuhiro, Yasuma, Reo, Li, Shengjian, Fowler, Benjamin J., Bastos-Carvalho, Ana, Kerur, Nagaraj, Uittenbogaard, Annette, Han, Youn Seon, Lou, Dingyuan, Kleinman, Mark E., McDonald, W. Hayes, Núñez, Gabriel, Georgel, Philippe, Dunaief, Joshua L., Ambati, Jayakrishna
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481133/
https://ncbi.nlm.nih.gov/pubmed/26074074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.05.023
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