Iron toxicity in the retina requires Alu RNA and the NLRP3 inflammasome

Excess iron induces tissue damage and is implicated in age-related macular degeneration (AMD). Iron toxicity is widely attributed to hydroxyl radical formation through Fenton's reaction. We report that excess iron, but not other Fenton catalytic metals, induces activation of the NLRP3 inflammas...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Gelfand, Bradley D., Wright, Charles B., Kim, Younghee, Yasuma, Tetsuhiro, Yasuma, Reo, Li, Shengjian, Fowler, Benjamin J., Bastos-Carvalho, Ana, Kerur, Nagaraj, Uittenbogaard, Annette, Han, Youn Seon, Lou, Dingyuan, Kleinman, Mark E., McDonald, W. Hayes, Núñez, Gabriel, Georgel, Philippe, Dunaief, Joshua L., Ambati, Jayakrishna
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481133/
https://ncbi.nlm.nih.gov/pubmed/26074074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.05.023
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