Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice

PURPOSE: To evaluate the efficacy of nucleoside reverse transcriptase inhibitors (NRTIs) in the laser-induced mouse model of choroidal neovascularization (CNV). METHODS: We evaluated the NRTIs lamivudine (3TC), zidovudine (AZT), and abacavir (ABC) and the P2X7 antagonist A438079. Choroidal neovascul...

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Publicat a:Invest Ophthalmol Vis Sci
Autors principals: Mizutani, Takeshi, Fowler, Benjamin J., Kim, Younghee, Yasuma, Reo, Krueger, Laura A., Gelfand, Bradley D., Ambati, Jayakrishna
Format: Artigo
Idioma:Inglês
Publicat: The Association for Research in Vision and Ophthalmology 2015
Matèries:
Retinal Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634627/
https://ncbi.nlm.nih.gov/pubmed/26529046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-17440
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