A Clinical Metabolite of Azidothymidine Inhibits Experimental Choroidal Neovascularization and Retinal Pigmented Epithelium Degeneration

PURPOSE: Azidothymidine (AZT), a nucleoside reverse transcriptase inhibitor, possesses anti-inflammatory and anti-angiogenic activity independent of its ability to inhibit reverse transcriptase. The aim of this study was to evaluate the efficacy of 5′-glucuronyl azidothymidine (GAZT), an antiretrovi...

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Veröffentlicht in:Invest Ophthalmol Vis Sci
Hauptverfasser: Narendran, Siddharth, Pereira, Felipe, Yerramothu, Praveen, Apicella, Ivana, Wang, Shao-bin, Varshney, Akhil, Baker, Kirstie L., Marion, Kenneth M., Ambati, Meenakshi, Ambati, Vidya L., Ambati, Kameshwari, Sadda, Srinivas R., Gelfand, Bradley D., Ambati, Jayakrishna
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Association for Research in Vision and Ophthalmology 2020
Schlagworte:
Retina
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7441363/
https://ncbi.nlm.nih.gov/pubmed/32749462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.10.4
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