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Enzyme assays for synthesis and degradation of 2-5As and other 2′-5′ oligonucleotides
BACKGROUND: The 5′-triphosphorylated, 2′-5′-linked oligoadenylate polyribonucleotides (2-5As) are central to the interferon-induced antiviral 2-5A system. The 2-5As bind and activate the RNase L, an endoRNase degrading viral and cellular RNA leading to inhibition of viral replication. The 2-5A syste...
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| Pubblicato in: | BMC Biochem |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4481073/ https://ncbi.nlm.nih.gov/pubmed/26113370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12858-015-0043-8 |
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