Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism

BACKGROUND: The expression of 2′-5′-Oligoadenylate synthetases (OASs) is induced by type 1 Interferons (IFNs) in response to viral infection. The OAS proteins have a unique ability to produce 2′-5′ Oligoadenylates, which bind and activate the ribonuclease RNase L. The RNase L degrades cellular RNAs...

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Main Authors: Kjær, Karina Hansen, Pahus, Jytte, Hansen, Mariann Fagernæs, Poulsen, Jesper Buchhave, Christensen, Erik Ilsø, Justesen, Just, Martensen, Pia Møller
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165621/
https://ncbi.nlm.nih.gov/pubmed/25205466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-15-33
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