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Enzyme assays for synthesis and degradation of 2-5As and other 2′-5′ oligonucleotides

BACKGROUND: The 5′-triphosphorylated, 2′-5′-linked oligoadenylate polyribonucleotides (2-5As) are central to the interferon-induced antiviral 2-5A system. The 2-5As bind and activate the RNase L, an endoRNase degrading viral and cellular RNA leading to inhibition of viral replication. The 2-5A syste...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:BMC Biochem
Egile Nagusiak: Poulsen, Jesper Buchhave, Kjær, Karina Hansen, Justesen, Just, Martensen, Pia Møller
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2015
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481073/
https://ncbi.nlm.nih.gov/pubmed/26113370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12858-015-0043-8
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