SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing

BACKGROUND: SIRT1 is likely to play a role in the extension in healthspan induced by dietary restriction. Actions of SIRT1 are pleiotropic, and effects on healthspan may include effects on DNA methylation. Polycomb group protein target genes (PCGTs) are suppressed by epigenetic mechanisms in stem ce...

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Detaylı Bibliyografya
Yayımlandı:Hum Genomics
Asıl Yazarlar: Wakeling, Luisa A, Ions, Laura J, Escolme, Suzanne M, Cockell, Simon J, Su, Tianhong, Dey, Madhurima, Hampton, Emily V, Jenkins, Gail, Wainwright, Linda J, McKay, Jill A, Ford, Dianne
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2015
Konular:
Primary Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480908/
https://ncbi.nlm.nih.gov/pubmed/26104761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40246-015-0036-0
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