SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing

BACKGROUND: SIRT1 is likely to play a role in the extension in healthspan induced by dietary restriction. Actions of SIRT1 are pleiotropic, and effects on healthspan may include effects on DNA methylation. Polycomb group protein target genes (PCGTs) are suppressed by epigenetic mechanisms in stem ce...

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Bibliografiske detaljer
Udgivet i:Hum Genomics
Main Authors: Wakeling, Luisa A, Ions, Laura J, Escolme, Suzanne M, Cockell, Simon J, Su, Tianhong, Dey, Madhurima, Hampton, Emily V, Jenkins, Gail, Wainwright, Linda J, McKay, Jill A, Ford, Dianne
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Primary Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480908/
https://ncbi.nlm.nih.gov/pubmed/26104761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40246-015-0036-0
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