SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing

BACKGROUND: SIRT1 is likely to play a role in the extension in healthspan induced by dietary restriction. Actions of SIRT1 are pleiotropic, and effects on healthspan may include effects on DNA methylation. Polycomb group protein target genes (PCGTs) are suppressed by epigenetic mechanisms in stem ce...

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Publicat a:Hum Genomics
Autors principals: Wakeling, Luisa A, Ions, Laura J, Escolme, Suzanne M, Cockell, Simon J, Su, Tianhong, Dey, Madhurima, Hampton, Emily V, Jenkins, Gail, Wainwright, Linda J, McKay, Jill A, Ford, Dianne
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Primary Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480908/
https://ncbi.nlm.nih.gov/pubmed/26104761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40246-015-0036-0
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