A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells

Here, we described a novel regulatory feedback loop in which hypoxia induces integrin-linked kinase (ILK) expression through a HIF-1α-dependent mechanism and ILK, in turn, stimulates HIF-1α expression through cell type- and cell context-dependent pathways. HIF-1α increased ILK via transcriptional ac...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Chou, Chih-Chien, Chuang, Hsaio-Ching, Salunke, Santosh B., Kulp, Samuel K., Chen, Ching-Shih
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480751/
https://ncbi.nlm.nih.gov/pubmed/25821081
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