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Effectiveness, safety and costs of orphan drugs: an evidence-based review

INTRODUCTION: Several orphan drugs have been approved by the European Medicines Agency (EMA) over the past two decades. However, the drugs are expensive, and in some instances, the evidence for effectiveness is not convincing at the time of regulatory approval. Our objective was to evaluate the clin...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:BMJ Open
Main Authors: Onakpoya, Igho J, Spencer, Elizabeth A, Thompson, Matthew J, Heneghan, Carl J
פורמט: Artigo
שפה:Inglês
יצא לאור: BMJ Publishing Group 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480037/
https://ncbi.nlm.nih.gov/pubmed/26109112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2014-007199
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