Low prevalence of germline hMSH6 mutations in colorectal cancer families from Spain

AIM: To investigate the prevalence and penetrance of hMSH6 mutations in Spanish HNPCC families that was negative for mutation in hMLH1 or hMSH2. METHODS: We used PCR-based DGGE assay and direct sequencing to screen for hMSH6 gene in 91 HNPCC families. RESULTS: we have identified 10 families with ger...

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Dettagli Bibliografici
Pubblicato in:World J Gastroenterol
Autori principali: de Abajo, Ana Sánchez, de la Hoya, Miguel, Tosar, Alicia, Godino, Javier, Fernández, Juan Manuel, Asenjo, Jose Lopez, Villamil, Beatriz Perez, Segura, Pedro Perez, Diaz-Rubio, Eduardo, Caldes, Trinidad
Natura: Artigo
Lingua:Inglês
Pubblicazione: Baishideng Publishing Group Inc 2005
Soggetti:
Colorectal Cancer
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479674/
https://ncbi.nlm.nih.gov/pubmed/16270383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v11.i37.5770
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