Loss or Somatic Mutations of hMSH2 Occur in Hereditary Nonpolyposis Colorectal Cancers with hMSH2 Germline Mutations

Hereditary nonpolyposis colorectal cancer (HNPCC) is a major cancer susceptibility syndrome known to be caused by the inheritance of mutations in DNA mismatch repair genes, such as hMSH2, hMLH1, hPMS1 and hPMS2. To investigate the role of genetic alterations of hMSH2 in HNPCC tumorigenesis, we analy...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Lu, Shi‐Long, Akiyama, Yoshimitsu, Nagasaki, Hiromi, Nomizu, Tadashi, Ikeda, Eiichi, Baba, Shozo, Ushio, Kyosuke, Iwama, Takeo, Maruyama, Kazuo, Yuasa, Yasuhito
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1996
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921088/
https://ncbi.nlm.nih.gov/pubmed/8613431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1996.tb00218.x
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