Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97

Patients with type 1 diabetes (T1D) suffer from beta-cell destruction by CD8(+) T-cells that have preproinsulin as an important target autoantigen. It is of great importance to understand the molecular mechanism underlying the processing of preproinsulin into these CD8(+) T-cell epitopes. We therefo...

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Publicado no:PLoS One
Main Authors: Hoelen, Hanneke, Zaldumbide, Arnaud, van Leeuwen, Wouter F., Torfs, Ellen C. W., Engelse, Marten A., Hassan, Chopie, Lebbink, Robert Jan, de Koning, Eelco J., Resssing, Maaike E., de Ru, Arnoud H., van Veelen, Peter A., Hoeben, Rob C., Roep, Bart O., Wiertz, Emmanuel J. H. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479611/
https://ncbi.nlm.nih.gov/pubmed/26107514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128206
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