Genetically Engineered Human Islets Protected From CD8-mediated Autoimmune Destruction In Vivo

Islet transplantation is a promising therapy for type 1 diabetes, but graft function and survival are compromised by recurrent islet autoimmunity. Immunoprotection of islets will be required to improve clinical outcome. We engineered human β cells to express herpesvirus-encoded immune-evasion protei...

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Detalhes bibliográficos
Main Authors: Zaldumbide, Arnaud, Alkemade, Gonnie, Carlotti, Françoise, Nikolic, Tatjana, Abreu, Joana RF, Engelse, Marten A, Skowera, Anja, de Koning, Eelco J, Peakman, Mark, Roep, Bart O, Hoeben, Rob C, Wiertz, Emmanuel JHJ
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734667/
https://ncbi.nlm.nih.gov/pubmed/23689598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.105
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