Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells

BACKGROUND: Valosin containing protein (VCP) is a critical mediator of protein homeostasis and may represent a valuable therapeutic target for several forms of cancer. Overexpression of VCP occurs in many cancers, and often in a manner correlating with malignancy and poor outcome. Here, we analyzed...

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Detaylı Bibliyografya
Yayımlandı:BMC Cancer
Asıl Yazarlar: Nadeau, Marie-Ève, Rico, Charlène, Tsoi, Mayra, Vivancos, Mélanie, Filimon, Sabin, Paquet, Marilène, Boerboom, Derek
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479320/
https://ncbi.nlm.nih.gov/pubmed/26104798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1489-1
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