Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

Mutations in valosin-containing protein (VCP) cause inclusion body myopathy (IBM), Paget's disease of the bone, and frontotemporal dementia (IBMPFD). Patient muscle has degenerating fibers, rimmed vacuoles (RVs), and sarcoplasmic inclusions containing ubiquitin and TDP-43 (TARDNA-binding protei...

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Detalhes bibliográficos
Main Authors: Ju, Jeong-Sun, Fuentealba, Rodrigo A., Miller, Sara E., Jackson, Erin, Piwnica-Worms, David, Baloh, Robert H., Weihl, Conrad C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806317/
https://ncbi.nlm.nih.gov/pubmed/20008565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200908115
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