Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

Mutations in valosin-containing protein (VCP) cause inclusion body myopathy (IBM), Paget's disease of the bone, and frontotemporal dementia (IBMPFD). Patient muscle has degenerating fibers, rimmed vacuoles (RVs), and sarcoplasmic inclusions containing ubiquitin and TDP-43 (TARDNA-binding protei...

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Bibliografiska uppgifter
Huvudupphovsmän: Ju, Jeong-Sun, Fuentealba, Rodrigo A., Miller, Sara E., Jackson, Erin, Piwnica-Worms, David, Baloh, Robert H., Weihl, Conrad C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2009
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806317/
https://ncbi.nlm.nih.gov/pubmed/20008565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200908115
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