Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia

Several lines of evidence implicate excess glucagon secretion in the elevated rates of hepatic glucose production (HGP), hyperglycemia, and ketosis characteristic of uncontrolled insulin-deficient diabetes (uDM), but whether hyperglucagonemia is required for hyperglycemia in this setting is unknown....

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Опубликовано в: :Diabetes
Главные авторы: Meek, Thomas H., Dorfman, Mauricio D., Matsen, Miles E., Fischer, Jonathan D., Cubelo, Alexis, Kumar, Monica R., Taborsky, Gerald J., Morton, Gregory J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2015
Предметы:
Metabolism
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477352/
https://ncbi.nlm.nih.gov/pubmed/25633417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-1562
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