Leptin Action in the Ventromedial Hypothalamic Nucleus Is Sufficient, But Not Necessary, to Normalize Diabetic Hyperglycemia

In rodent models of type 1 diabetes, leptin administration into brain ventricles normalizes blood glucose at doses that have no effect when given peripherally. The ventromedial nucleus of the hypothalamus (VMN) is a potential target for leptin's antidiabetic effects because leptin-sensitive neu...

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Detalhes bibliográficos
Main Authors: Meek, Thomas H., Matsen, Miles E., Dorfman, Mauricio D., Guyenet, Stephan J., Damian, Vincent, Nguyen, Hong T., Taborsky, Gerald J., Morton, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Diabetes-Insulin-Glucagon-Gastrointestinal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749482/
https://ncbi.nlm.nih.gov/pubmed/23782941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1328
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