Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia

Several lines of evidence implicate excess glucagon secretion in the elevated rates of hepatic glucose production (HGP), hyperglycemia, and ketosis characteristic of uncontrolled insulin-deficient diabetes (uDM), but whether hyperglucagonemia is required for hyperglycemia in this setting is unknown....

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Bibliografische gegevens
Gepubliceerd in:Diabetes
Hoofdauteurs: Meek, Thomas H., Dorfman, Mauricio D., Matsen, Miles E., Fischer, Jonathan D., Cubelo, Alexis, Kumar, Monica R., Taborsky, Gerald J., Morton, Gregory J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Diabetes Association 2015
Onderwerpen:
Metabolism
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477352/
https://ncbi.nlm.nih.gov/pubmed/25633417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-1562
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