Conformationally Strained trans-Cyclooctene with Improved Stability and Excellent Reactivity in Tetrazine Ligation

Computation has guided the design of conformationally-strained dioxolane-fused trans-cyclooctene (d-TCO) derivatives that display excellent reactivity in the tetrazine ligation. A water soluble derivative of 3,6-dipyridyl-s-tetrazine reacts with d-TCO with a second order rate k(2) 366,000 (+/− 15,00...

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Detaylı Bibliyografya
Yayımlandı:Chem Sci
Asıl Yazarlar: Darko, Ampofo, Wallace, Stephen, Dmitrenko, Olga, Machovina, Melodie M., Mehl, Ryan A., Chin, Jason W., Fox, Joseph M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477040/
https://ncbi.nlm.nih.gov/pubmed/26113970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4SC01348D
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