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Architecture of the polyketide synthase module: surprises from electron cryo-microscopy

Modular polyketide synthases produce a vast array of bioactive molecules that are the basis of many highly valued pharmaceuticals. The biosynthesis of these compounds is based on ordered assembly lines of multi-domain modules, each extending and modifying a specific chain-elongation intermediate bef...

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Dades bibliogràfiques
Publicat a:Curr Opin Struct Biol
Autors principals: Smith, Janet L, Skiniotis, Georgios, Sherman, David H
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476912/
https://ncbi.nlm.nih.gov/pubmed/25791608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2015.02.014
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