Age at Mycobacterium bovis BCG Priming Has Limited Impact on Anti-Tuberculosis Immunity Boosted by Respiratory Mucosal AdHu5Ag85A Immunization in a Murine Model

Tuberculosis (TB) remains a global pandemic despite the use of Bacillus Calmette-Guérin (BCG) vaccine, partly because BCG fails to effectively control adult pulmonary TB. The introduction of novel boost vaccines such as the human Adenovirus 5-vectored AdHu5Ag85A could improve and prolong the protect...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Damjanovic, Daniela, Khera, Amandeep, Afkhami, Sam, Lai, Rocky, Zganiacz, Anna, Jeyanathan, Mangalakumari, Xing, Zhou
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476612/
https://ncbi.nlm.nih.gov/pubmed/26098423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131175
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