Goats Primed with Mycobacterium bovis BCG and Boosted with a Recombinant Adenovirus Expressing Ag85A Show Enhanced Protection against Tuberculosis

This is the first efficacy study using the experimental goat model, a natural host of tuberculosis (TB), to evaluate the efficacy of heterologous Mycobacterium bovis bacillus Calmette-Guérin (BCG) prime followed by boosting with a replication-deficient adenovirus expressing the antigen Ag85A (AdAg85...

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Bibliographische Detailangaben
Hauptverfasser: Pérez de Val, Bernat, Villarreal-Ramos, Bernardo, Nofrarías, Miquel, López-Soria, Sergio, Romera, Nadine, Singh, Mahavir, Abad, F. Xavier, Xing, Zhou, Vordermeier, H. Martin, Domingo, Mariano
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428397/
https://ncbi.nlm.nih.gov/pubmed/22761299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00275-12
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