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Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD
In this study, we identified a BET bromodomain (BRD) protein, Brd4, not only as a novel epigenetic regulator of autosomal dominant polycystic kidney disease (ADPKD) but also as a novel client protein of Hsp90. We found that Brd4 was upregulated in Pkd1 mutant mouse renal epithelial cells and tissues...
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| Vydáno v: | Hum Mol Genet |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4476445/ https://ncbi.nlm.nih.gov/pubmed/25877301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv136 |
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