An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma

High-grade serous ovarian carcinoma (HGSOC) is the most common and aggressive form of epithelial ovarian cancer, for which few targeted therapies exist. To search for new therapeutic target proteins, we performed an in vivo shRNA screen using an established human HGSOC cell line growing either subcu...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Baratta, Maria Giuseppina, Schinzel, Anna C., Zwang, Yaara, Bandopadhayay, Pratiti, Bowman-Colin, Christian, Kutt, Jennifer, Curtis, Jennifer, Piao, Huiying, Wong, Laura C., Kung, Andrew L., Beroukhim, Rameen, Bradner, James E., Drapkin, Ronny, Hahn, William C., Liu, Joyce F., Livingston, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291641/
https://ncbi.nlm.nih.gov/pubmed/25535366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422165112
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