Selective BET bromodomain inhibition as an antifungal therapeutic strategy

Invasive fungal infections cause significant morbidity and mortality among immunocompromised individuals, posing an urgent need for new antifungal therapeutic strategies. Here we investigate a chromatin-interacting module, the bromodomain (BD) from the BET family of proteins, as a potential antifung...

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Pubblicato in:Nat Commun
Autori principali: Mietton, Flore, Ferri, Elena, Champleboux, Morgane, Zala, Ninon, Maubon, Danièle, Zhou, Yingsheng, Harbut, Mike, Spittler, Didier, Garnaud, Cécile, Courçon, Marie, Chauvel, Murielle, d'Enfert, Christophe, Kashemirov, Boris A., Hull, Mitchell, Cornet, Muriel, McKenna, Charles E., Govin, Jérôme, Petosa, Carlo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454392/
https://ncbi.nlm.nih.gov/pubmed/28516956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15482
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