Voltage-gated Na(+) Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling

Functional expression of voltage-gated Na(+) channels (VGSCs) has been demonstrated in multiple cancer cell types where channel activity induces invasive activity. The signaling mechanisms by which VGSCs promote oncogenesis remain poorly understood. We explored the signal transduction process critic...

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Udgivet i:Sci Rep
Main Authors: House, Carrie D., Wang, Bi-Dar, Ceniccola, Kristin, Williams, Russell, Simaan, May, Olender, Jacqueline, Patel, Vyomesh, Baptista-Hon, Daniel T., Annunziata, Christina M., Silvio Gutkind, J., Hales, Tim G., Lee, Norman H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476109/
https://ncbi.nlm.nih.gov/pubmed/26096612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11541
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