Voltage-gated Na(+) Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling

Functional expression of voltage-gated Na(+) channels (VGSCs) has been demonstrated in multiple cancer cell types where channel activity induces invasive activity. The signaling mechanisms by which VGSCs promote oncogenesis remain poorly understood. We explored the signal transduction process critic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: House, Carrie D., Wang, Bi-Dar, Ceniccola, Kristin, Williams, Russell, Simaan, May, Olender, Jacqueline, Patel, Vyomesh, Baptista-Hon, Daniel T., Annunziata, Christina M., Silvio Gutkind, J., Hales, Tim G., Lee, Norman H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476109/
https://ncbi.nlm.nih.gov/pubmed/26096612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11541
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