Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally-aging mice

Subclinical vitamin C deficiency is widespread in many populations, but its role in both Alzheimer’s disease and normal aging is understudied. In the present study we decreased brain vitamin C in the APP(SWE)/PSEN1(deltaE9) mouse model of Alzheimer’s disease, by crossing APP/PSEN1(+) bigenic mice wi...

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Vydáno v:ACS Chem Neurosci
Hlavní autoři: Dixit, Shilpy, Bernardo, Alexandra, Walker, Michelle Jennifer, Kennard, John Andrew, Kim, Grace Youngeun, Kessler, Eric Sean, Harrison, Fiona Edith
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476071/
https://ncbi.nlm.nih.gov/pubmed/25642732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500308h
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