Altered glutamate clearance in ascorbate deficient mice increases seizure susceptibility and contributes to cognitive impairment in APP/PSEN1 mice

Ascorbate (vitamin C) is critical as a first line of defense antioxidant within the brain, and specifically within the synapse. Ascorbate is released by astrocytes during glutamate clearance and disruption of this exchange mechanism may be critical in mediating glutamate toxicity within the synapse....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neurobiol Aging
Prif Awduron: Mi, Deborah J, Dixit, Shilpy, Warner, Timothy A, Kennard, John A, Scharf, Daniel A, Kessler, Eric S, Moore, Lisa M, Consoli, David C, Bown, Corey W, Eugene, Angeline J, Kang, Jing-Qiong, Harrison, Fiona E
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162152/
https://ncbi.nlm.nih.gov/pubmed/30172223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.08.002
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