Altered glutamate clearance in ascorbate deficient mice increases seizure susceptibility and contributes to cognitive impairment in APP/PSEN1 mice

Ascorbate (vitamin C) is critical as a first line of defense antioxidant within the brain, and specifically within the synapse. Ascorbate is released by astrocytes during glutamate clearance and disruption of this exchange mechanism may be critical in mediating glutamate toxicity within the synapse....

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Publicado no:Neurobiol Aging
Main Authors: Mi, Deborah J, Dixit, Shilpy, Warner, Timothy A, Kennard, John A, Scharf, Daniel A, Kessler, Eric S, Moore, Lisa M, Consoli, David C, Bown, Corey W, Eugene, Angeline J, Kang, Jing-Qiong, Harrison, Fiona E
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162152/
https://ncbi.nlm.nih.gov/pubmed/30172223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.08.002
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