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Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally-aging mice
Subclinical vitamin C deficiency is widespread in many populations, but its role in both Alzheimer’s disease and normal aging is understudied. In the present study we decreased brain vitamin C in the APP(SWE)/PSEN1(deltaE9) mouse model of Alzheimer’s disease, by crossing APP/PSEN1(+) bigenic mice wi...
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| Publicado no: | ACS Chem Neurosci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4476071/ https://ncbi.nlm.nih.gov/pubmed/25642732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500308h |
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