Germline Alterations of the RNASEL Gene, a Candidate HPC1 Gene at 1q25, in Patients and Families with Prostate Cancer

The RNASEL gene (2′,5′-oligoisoadenylate-synthetase dependent) encodes a ribonuclease that mediates the antiviral and apoptotic activities of interferons. The RNASEL gene maps to the hereditary-prostate-cancer (HPC)–predisposition locus at 1q24-q25 (HPC1) and was recently shown to harbor truncating...

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Main Authors: Rökman, Annika, Ikonen, Tarja, Seppälä, Eija H., Nupponen, Nina, Autio, Ville, Mononen, Nina, Bailey-Wilson, Joan, Trent, Jeffrey, Carpten, John, Matikainen, Mika P., Koivisto, Pasi A., Tammela, Teuvo L. J., Kallioniemi, Olli-P., Schleutker, Johanna
Formato: Artigo
Idioma:Inglês
Publicado: The American Society of Human Genetics 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC447604/
https://ncbi.nlm.nih.gov/pubmed/11941539
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