A missense substitution A49T in the steroid 5-alpha-reductase gene (SRD5A2) is not associated with prostate cancer in Finland

Prostatic steroid 5-alpha-reductase gene (SRD5A2) encodes a critical enzyme involved in the conversion of testosterone to dihydrotestosterone. A germline mis-sense substitution (A49T) leads to a variant SRD5A2 protein, which has a 5-fold higher in vitro V (max) than the wild-type protein (Ross et al...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mononen, N, Ikonen, T, Syrjäkoski, K, Matikainen, M, Schleutker, J, Tammela, T L J, Koivisto, P A, Kallioniemi, O P
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2001
Schlagworte:
Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363646/
https://ncbi.nlm.nih.gov/pubmed/11355945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.1789
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