Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism

Steroid hormones are essential in stress response, immune system regulation, and reproduction in mammals. Steroids with 3-oxo-Δ(4) structure, such as testosterone or progesterone, are catalyzed by steroid 5α-reductases (SRD5As) to generate their corresponding 3-oxo-5α steroids, which are essential f...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Han, Yufei, Zhuang, Qian, Sun, Bo, Lv, Wenping, Wang, Sheng, Xiao, Qingjie, Pang, Bin, Zhou, Youli, Wang, Fuxing, Chi, Pengliang, Wang, Qisheng, Li, Zhen, Zhu, Lizhe, Li, Fuping, Deng, Dong, Chiang, Ying-Chih, Li, Zhenfei, Ren, Ruobing
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815742/
https://ncbi.nlm.nih.gov/pubmed/33469028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20675-2
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