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BET bromodomain inhibition suppresses the functional output of hematopoietic transcription factors in acute myeloid leukemia
The bromodomain and extraterminal (BET) protein BRD4 is a validated drug target in leukemia, yet its regulatory function in this disease is not well understood. Here, we show that BRD4 chromatin occupancy in acute myeloid leukemia closely correlates with the hematopoietic transcription factors (TFs)...
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| Publié dans: | Mol Cell |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4475489/ https://ncbi.nlm.nih.gov/pubmed/25982114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.04.011 |
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