USP18 lack in microglia causes destructive interferonopathy of the mouse brain

Microglia are tissue macrophages of the central nervous system (CNS) that control tissue homeostasis. Microglia dysregulation is thought to be causal for a group of neuropsychiatric, neurodegenerative and neuroinflammatory diseases, called “microgliopathies”. However, how the intracellular stimulati...

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Publicat a:EMBO J
Autors principals: Goldmann, Tobias, Zeller, Nicolas, Raasch, Jenni, Kierdorf, Katrin, Frenzel, Kathrin, Ketscher, Lars, Basters, Anja, Staszewski, Ori, Brendecke, Stefanie M, Spiess, Alena, Tay, Tuan Leng, Kreutz, Clemens, Timmer, Jens, Mancini, Grazia MS, Blank, Thomas, Fritz, Günter, Biber, Knut, Lang, Roland, Malo, Danielle, Merkler, Doron, Heikenwälder, Mathias, Knobeloch, Klaus-Peter, Prinz, Marco
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475397/
https://ncbi.nlm.nih.gov/pubmed/25896511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490791
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