Artificial Recruitment of UAF1-USP Complexes by a PHLPP1-E1 Chimeric Helicase Enhances Human Papillomavirus DNA Replication

The E1 helicase from anogenital human papillomavirus (HPV) types interacts with the cellular WD repeat-containing protein UAF1 in complex with the deubiquitinating enzyme USP1, USP12, or USP46. This interaction stimulates viral DNA replication and is required for maintenance of the viral episome in...

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Bibliographic Details
Published in:J Virol
Main Authors: Gagnon, David, Lehoux, Michaël, Archambault, Jacques
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474315/
https://ncbi.nlm.nih.gov/pubmed/25833051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00560-15
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