A Conserved Amphipathic Helix in the N-Terminal Regulatory Region of the Papillomavirus E1 Helicase Is Required for Efficient Viral DNA Replication

The papillomavirus E1 helicase, with the help of E2, assembles at the viral origin into a double hexamer that orchestrates replication of the viral genome. The N-terminal region (NTR) of E1 is essential for DNA replication in vivo but dispensable in vitro, suggesting that it has a regulatory functio...

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Bibliographic Details
Main Authors: Morin, Geneviève, Fradet-Turcotte, Amélie, Di Lello, Paola, Bergeron-Labrecque, Fanny, Omichinski, James G., Archambault, Jacques
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094988/
https://ncbi.nlm.nih.gov/pubmed/21450828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01829-10
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