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Nuclear Accumulation of the Papillomavirus E1 Helicase Blocks S-Phase Progression and Triggers an ATM-Dependent DNA Damage Response

Replication of the papillomavirus genome is initiated by the assembly of a complex between the viral E1 and E2 proteins at the origin. The E1 helicase is comprised of a C-terminal ATPase/helicase domain, a central domain that binds to the origin, and an N-terminal regulatory region that contains nuc...

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Bibliografische gegevens
Hoofdauteurs: Fradet-Turcotte, Amélie, Bergeron-Labrecque, Fanny, Moody, Cary A., Lehoux, Michaël, Laimins, Laimonis A., Archambault, Jacques
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165840/
https://ncbi.nlm.nih.gov/pubmed/21734051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00542-11
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