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Genetic Determinants of Japanese Encephalitis Virus Vaccine Strain SA14-14-2 That Govern Attenuation of Virulence in Mice

The safety and efficacy of the live-attenuated Japanese encephalitis virus (JEV) SA14-14-2 vaccine are attributed to mutations that accumulated in the viral genome during its derivation. However, little is known about the contribution that is made by most of these mutations to virulence attenuation...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Gromowski, Gregory D., Firestone, Cai-Yen, Whitehead, Stephen S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474313/
https://ncbi.nlm.nih.gov/pubmed/25855730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00219-15
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