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Genetic and Phenotypic Properties of Vero Cell-Adapted Japanese Encephalitis Virus SA14-14-2 Vaccine Strain Variants and a Recombinant Clone, which Demonstrates Attenuation and Immunogenicity in Mice
The live-attenuated Japanese encephalitis virus (JEV) SA14-14-2 vaccine, produced in primary hamster kidney cells, is safe and effective. Past attempts to adapt this virus to replicate in cells that are more favorable for vaccine production resulted in mutations that significantly reduced immunogeni...
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| Publié dans: | Am J Trop Med Hyg |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society of Tropical Medicine and Hygiene
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4347400/ https://ncbi.nlm.nih.gov/pubmed/25311701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.14-0427 |
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