Chimeric Japanese Encephalitis Virus SA14/SA14-14-2 Was Virulence Attenuated and Protected the Challenge of Wild-Type Strain SA14

The attenuated Japanese encephalitis virus (JEV) live vaccine SA14-14-2 prepared from wild-type (WT) strain SA14 was licensed to prevent Japanese encephalitis (JE) in 1989 in China. Many studies showed that the premembrane (prM) and envelope (E) protein were the crucial determinant of virulence and...

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Publicado en:Can J Infect Dis Med Microbiol
Autores principales: Huang, Rong, Leng, Shengling, Feng, Yalan, Tang, Liping, Yuan, Lei, Yang, Jian
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421771/
https://ncbi.nlm.nih.gov/pubmed/30944684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/9179308
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