Incidence and extent of TDP-43 accumulation in aging human brain

INTRODUCTION: The transactivation response element DNA-binding protein 43 kDa (TDP-43) is a major component of the ubiquitin-positive and tau-negative inclusions in frontotemporal lobar degeneration and sporadic amyotrophic lateral sclerosis (ALS). TDP-43 may accumulate in cases of Alzheimer’s disea...

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Publicado en:Acta Neuropathol Commun
Autores principales: Uchino, Akiko, Takao, Masaki, Hatsuta, Hiroyuki, Sumikura, Hiroyuki, Nakano, Yuta, Nogami, Akane, Saito, Yuko, Arai, Tomio, Nishiyama, Kazutoshi, Murayama, Shigeo
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473839/
https://ncbi.nlm.nih.gov/pubmed/26091809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0215-1
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